Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995072 | 0.85 | MLYCD (0.46) | TSHRHTTTP53PLA2G4B | |
| Hydrochloric Acid SCHEMBL8994855 | 0.83 | PRSS1 (0.61) | PDE10APLAU | |
| SCHEMBL8995027 | 0.82 | NPC1 (0.54) | TSHRHTTTP53NPC1POLB | |
| SCHEMBL8994945 | 0.80 | LTB4R (0.55) | TSHRPLAUHTTTP53PLA2G4B | |
| SCHEMBL7213360 | 0.77 | TP53 (0.59) | TSHRPLAUTP53NPC1RAB9A | |
| SCHEMBL20333167 | 0.77 | PRMT1 (0.53) | TSHRPLAUHTTTP53 | |
| Hydrochloric Acid SCHEMBL9139776 | 0.76 | HPGD (0.45) | TP53 | |
| SCHEMBL8994960 | 0.76 | LMNA (0.50) | NPC1RAB9APLA2G4B | |
| SCHEMBL8994969 | 0.76 | PRMT1 (0.51) | TSHRPLAUHTTTP53 | |
| Hydrochloric Acid SCHEMBL9118862 | 0.75 | PDE10A (0.49) | PDE10AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |