Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995027 | 0.91 | NPC1 (0.54) | LMNANPC1RAB9ASMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8994879 | 0.84 | PRSS1 (0.62) | PRSS1 | |
| SCHEMBL8994940 | 0.82 | MAPT (0.52) | LMNANPC1RAB9ASMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8994944 | 0.77 | PRSS1 (0.68) | HRH3PRSS1 | |
| SCHEMBL8994945 | 0.76 | LTB4R (0.55) | L3MBTL1PLA2G4BHRH3KMT2A | |
| SCHEMBL8995101 | 0.76 | PDE10A (0.51) | NPC1RAB9APLA2G4B | |
| SCHEMBL20333167 | 0.76 | PRMT1 (0.53) | HRH3PRSS1 | |
| SCHEMBL8995072 | 0.76 | MLYCD (0.46) | LMNASMN1; SMN2L3MBTL1PLA2G4BTDP1 | |
| Hydrochloric Acid SCHEMBL8994889 | 0.75 | LMNA (0.47) | LMNANPC1RAB9ASMN1; SMN2PLA2G4B | |
| SCHEMBL3731767 | 0.74 | TP53 (0.50) | LMNANPC1RAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |