SCHEMBL8995939

SCHEMBL8995939

C=CC(=O)NCc1ccc(Nc2ccc(C)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 2/20 0.59
LMNA P02545 2/20 0.56
NPC1 O15118 3/20 0.55
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 4/20 0.49
KMT2A Q03164 2/20 0.48
TP53 P04637 2/20 0.48
HPGD P15428 2/20 0.48
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 2/20 0.47
GAA P10253 1/20 0.47
JAK2 O60674 1/20 0.47
JAK1 P23458 1/20 0.47
TYK2 P29597 1/20 0.47
FLT3 P36888 1/20 0.47
JAK3 P52333 1/20 0.47
KDM4E B2RXH2 2/20 0.46
MAPT P10636 1/20 0.46
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL959540 0.92 TGM2 (0.69) TGM2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL261979 0.86 TGM2 (0.61) TGM2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL8995937 0.84 TGM2 (0.59) TGM2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL732934 0.83 TGM2 (0.81) TGM2LMNAKMT2AMEN1ALDH1A1
SCHEMBL395033 0.82 LMNA (0.66) LMNASMN1; SMN2KMT2AHPGDMEN1
SCHEMBL3824015 0.82 LMNA (0.66) LMNASMN1; SMN2KMT2AHPGDMEN1
SCHEMBL8995961 0.81 MEN1 (0.60) TGM2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL16054746 0.81 TGM2 (0.49) TGM2LMNAJAK2JAK1TYK2
SCHEMBL7784363 0.80 ALDH1A1 (0.54) TGM2LMNAKMT2ATP53MEN1
SCHEMBL8465028 0.78 TGM2 (0.89) TGM2LMNAALDH1A1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025102500-A1 NITRILE RUBBER, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国石油天然气股份有限公司 2025-05-22 WO claimed
US-4376846-A OIL AND OZONE RESISTANT AND HEAT AGING RESISTANT JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-03-15 US claimed
WO-2025102500-A1 NITRILE RUBBER, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国石油天然气股份有限公司 2025-05-22 WO disclosed
EP-0570825-B1 Tire sidewall composition containing silica having low PH GOODYEAR TIRE & RUBBER (US) 1996-08-07 EP disclosed
EP-0475215-B1 Carboxylic acid esters with thio groups GOODYEAR TIRE & RUBBER (US) 1994-10-19 EP disclosed
EP-0570825-A1 Tire sidewall composition containing silica having low PH THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-11-24 EP disclosed
US-5244028-A Natural rubber or polybutadiene, silica, antidegradation agent, carbon black THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-09-14 US disclosed
US-5216049-A A phenolic or amine stabilizer and an organothioalkylene styrene bound to a polymer; aging resistance; rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-06-01 US disclosed
EP-0475215-A1 Carboxylic acid esters with thio groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-03-18 EP disclosed
US-5069819-A SYNERGISTS FOR CONVENTIONAL PHENOLIC AND AMINE ANTIOXIDANTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-03 US disclosed
EP-0028999-B1 PROCESS FOR THE PREPARATION OF ANTIOXIDANT AMIDES THE GOODYEAR TIRE & RUBBER COMPANY (US) 1983-03-23 EP disclosed
US-4376846-A OIL AND OZONE RESISTANT AND HEAT AGING RESISTANT JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-03-15 US disclosed
US-4286105-A AMIDATION THE GOODYEAR TIRE & RUBBER COMPANY (US) 1981-08-25 US disclosed
EP-0028999-A1 Process for the preparation of antioxidant amides THE GOODYEAR TIRE & RUBBER COMPANY (US) 1981-05-20 EP disclosed