Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29774222 | 0.85 | BCHE (0.44) | MEN1KMT2A | |
| SCHEMBL1833138 | 0.80 | FDPS (0.43) | KCNH2ALDH1A1POLBFDPS | |
| SCHEMBL8065724 | 0.79 | LMNA (0.44) | — | |
| SCHEMBL11301094 | 0.79 | KCNH2 (0.42) | KCNH2ALDH1A1POLBFDPS | |
| SCHEMBL9062747 | 0.79 | ALOX15 (0.52) | MEN1KMT2AKCNH2ALDH1A1HTT | |
| SCHEMBL8995931 | 0.77 | FDPS (0.43) | MEN1KMT2AKCNH2ALDH1A1HTT | |
| SCHEMBL10912425 | 0.77 | TAAR1 (0.44) | MEN1KMT2AALDH1A1NPC1POLB | |
| SCHEMBL4933808 | 0.76 | AOX1 (0.42) | — | |
| SCHEMBL9129256 | 0.74 | KCNH2 (0.62) | KCNH2MAPT | |
| SCHEMBL8995954 | 0.74 | FDPS (0.39) | MEN1KMT2AKCNH2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | claimed |
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | claimed |
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | disclosed |
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |