Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9062747 | 0.78 | ALOX15 (0.52) | FDPSDPP7RORCALDH1A1HTT | |
| SCHEMBL917066 | 0.77 | HTT (0.37) | FDPSALDH1A1HTTRAB9AGAA | |
| SCHEMBL8995931 | 0.77 | FDPS (0.43) | FDPSDPP7RORCALDH1A1HTT | |
| SCHEMBL8995950 | 0.74 | MEN1 (0.39) | FDPSRORCALDH1A1HTTRAB9A | |
| SCHEMBL914853 | 0.71 | HTT (0.39) | FDPSALDH1A1HTTMAPTMEN1 | |
| SCHEMBL2834718 | 0.69 | MMP1 (0.32) | — | |
| SCHEMBL779433 | 0.69 | TRPM8 (0.45) | — | |
| SCHEMBL9129256 | 0.69 | KCNH2 (0.62) | MAPTKCNH2 | |
| SCHEMBL8987792 | 0.69 | ALOX5 (0.47) | ALDH1A1HTTRAB9AGAAMAPT | |
| SCHEMBL4623191 | 0.68 | PLA2G2C (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | claimed |
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | claimed |
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | disclosed |
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |