Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.36 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.36 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000601 | 0.95 | PLA2G2A (0.37) | GPR88LMNAMAPTNPC1TP53 | |
| SCHEMBL9000722 | 0.92 | SMN1; SMN2 (0.36) | GPR88LMNAMAPTNPC1TP53 | |
| SCHEMBL9000398 | 0.90 | EPHX1 (0.47) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9000588 | 0.90 | EPHX1 (0.38) | LMNASOAT1EPHX1ALDH1A1L3MBTL1 | |
| SCHEMBL9000651 | 0.88 | SOAT1 (0.41) | SMN1; SMN2SOAT1EPHX1ALDH1A1POLB | |
| SCHEMBL9000890 | 0.87 | SOAT1 (0.43) | LMNAMAPTNPC1TP53RAB9A | |
| SCHEMBL9000575 | 0.87 | SOAT1 (0.39) | MAPTSMN1; SMN2SOAT1MEN1ALDH1A1 | |
| SCHEMBL9000506 | 0.87 | SOAT1 (0.39) | LMNARAB9ASMN1; SMN2SOAT1ALDH1A1 | |
| SCHEMBL9000445 | 0.86 | POLB (0.43) | LMNAMAPTSOAT1EPHX1MEN1 | |
| SCHEMBL9000753 | 0.86 | SOAT1 (0.39) | LMNAMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |