Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000714 | 0.92 | GPR88 (0.39) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL9000601 | 0.91 | PLA2G2A (0.37) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL9000831 | 0.87 | TOP2A (0.37) | SMN1; SMN2RAB9AMAPTLMNA | |
| SCHEMBL9000603 | 0.87 | SOAT1 (0.35) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL9000890 | 0.86 | SOAT1 (0.43) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL9000768 | 0.84 | EPHX1 (0.41) | SMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL9000878 | 0.82 | EPHX1 (0.41) | SMN1; SMN2MAPTLMNAL3MBTL1CYP2C19 | |
| SCHEMBL9000588 | 0.82 | EPHX1 (0.38) | LMNAL3MBTL1CYP2C19 | |
| SCHEMBL9000398 | 0.82 | EPHX1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL9000898 | 0.81 | EPHX1 (0.46) | TP53NPC1RAB9AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |