Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016068 | 0.85 | TSHR (0.35) | TSHRALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2537839 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL2577552 | 0.80 | TSHR (0.54) | TSHRALDH1A1MEN1KMT2APOLB | |
| SCHEMBL7535141 | 0.78 | ALDH1A1 (0.38) | TSHRALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9514799 | 0.76 | DHFR (0.33) | — | |
| SCHEMBL3249889 | 0.75 | CHKA (0.36) | ESR1 | |
| SCHEMBL27539918 | 0.73 | CRHBP (0.40) | TSHRALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2037036 | 0.73 | ALDH1A1 (0.44) | TSHRALDH1A1MEN1KMT2AGLA | |
| SCHEMBL10326109 | 0.72 | TSHR (0.46) | TSHRALDH1A1MEN1KMT2APOLB | |
| SCHEMBL11794334 | 0.72 | ESR1 (0.31) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454260-B1 | IMMUNODETECTION AND QUANTIFICATION OF PYRAZOLOPYRIMIDINE SEDATIVES | RANDOX LAB LTD (GB) | 2016-11-16 | — | — | EP | disclosed |
| US-8852953-B2 | Immunodetection and quantification of pyrazolopyrimidine sedatives | RANDOX LABORATORIES LTD. (GB) | 2014-10-07 | — | — | US | disclosed |
| US-20120208294-A1 | IMMUNODETECTION AND QUANTIFICATION OF PYRAZOLOPYRIMIDINE SEDATIVES | RANDOX LABORATORIES LTD. (GB) | 2012-08-16 | — | — | US | disclosed |
| EP-2454260-A1 | IMMUNODETECTION AND QUANTIFICATION OF PYRAZOLOPYRIMIDINE SEDATIVES | Randox Laboratories Ltd. (GB) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011007180-A9 | IMMUNODETECTION AND QUANTIFICATION OF PYRAZOLOPYRIMIDINE SEDATIVES | RANDOX LABORATORIES LTD (GB) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011007180-A1 | IMMUNODETECTION AND QUANTIFICATION OF PYRAZOLOPYRIMIDINE SEDATIVES | RANDOX LABORATORIES LTD (GB) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208294-A1 | IMMUNODETECTION AND QUANTIFICATION OF PYRAZOLOPYRIMIDINE SEDATIVES | GABRA6, GABRP, GABRA5 | TSHR 1446/4885ALDH1A1 84/4885MEN1 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.