Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 7/20 | 0.36 |
| ▸ | CRY1 | Q16526 | 6/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 6/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004290 | 0.88 | PER2 (0.38) | L3MBTL1PER2CRY1CRY2BACE1 | |
| SCHEMBL8489932 | 0.84 | PER2 (0.42) | L3MBTL1PER2CRY1CRY2BACE1 | |
| SCHEMBL8488753 | 0.82 | PER2 (0.51) | L3MBTL1PER2CRY1CRY2BACE1 | |
| SCHEMBL8485649 | 0.82 | PER2 (0.40) | PER2CRY1CRY2BACE1 | |
| SCHEMBL8489489 | 0.80 | CRY1 (0.60) | PER2CRY1CRY2BACE1KMT2A | |
| SCHEMBL14873334 | 0.79 | MAPT (0.57) | MAPTATML3MBTL1ADRA2AADRA2B | |
| SCHEMBL18975267 | 0.77 | MEN1 (0.36) | MAPTATML3MBTL1ADRA2AADRA2B | |
| SCHEMBL18975289 | 0.77 | ADRA2A (0.37) | MAPTATML3MBTL1ADRA2AADRA2B | |
| SCHEMBL18975290 | 0.76 | SMN1; SMN2 (0.39) | MAPTATMADRA2AADRA2BADRA2C | |
| SCHEMBL8589196 | 0.76 | L3MBTL1 (0.40) | MAPTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730586-A1 | 1,4,7,10-TETRAAZACYCLODODECANE DERIVATIVES, THEIR USE, PHARMACEUTICALS CONTAINING THEM AND PROCESS FOR THEIR PRODUCTION | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014678-A1 | 1,4,7,10-TETRAAZACYCLODODECANE DERIVATIVES, THEIR USE, PHARMACEUTICALS CONTAINING THEM AND PROCESS FOR THEIR PRODUCTION | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-06-01 | — | — | WO | disclosed |