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SCHEMBL9007326

SCHEMBL9007326

CC(C)(C)c1cc(CC[SiH2]c2cccc(C(C)(C)C)c2C(C)(C)C)cc(C(C)(C)C)c1O.CC(C)(C)c1cc(CC[Si](C(C)(C)C)(C(C)(C)C)C(C)(C)C)cc(C(C)(C)C)c1O.Cc1cc(CC[Si](C)(C)C)cc(C)c1O.Cc1cccc([SiH2]CCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)c1C.Cc1cccc([SiH2]CCc2cc(C)c(O)c(C)c2)c1C

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ SCN2A Q99250 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8389486 0.92 — —
SCHEMBL6680819 0.82 PTGS1 (0.39) —
SCHEMBL8375519 0.80 — —
SCHEMBL6676515 0.80 SCN2A (0.43) SCN2A
SCHEMBL5692161 0.79 CA2 (0.43) SCN2A
SCHEMBL8375514 0.78 — —
SCHEMBL5692376 0.74 PTGS1 (0.42) —
SCHEMBL8385658 0.71 ALOX5 (0.32) —
SCHEMBL9007329 0.70 GAA (0.34) SCN2A
SCHEMBL9007397 0.70 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0732928-A1 METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS MERRELL PHARMACEUTICALS INC. (US) 1996-09-25 — — EP disclosed
WO-1995015760-A1 METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS MERRELL PHARMACEUTICALS INC. (US) 1995-06-15 — — WO disclosed