Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007494 | 0.85 | NQO1 (0.39) | NQO1MAPTPOLBL3MBTL1RECQL | |
| SCHEMBL9007525 | 0.82 | AKR1B1 (0.41) | THRBTHRAF10AKR1B1 | |
| SCHEMBL9007515 | 0.79 | KMT2A (0.39) | THRBMAPTKMT2AHPDTHRA | |
| SCHEMBL9007566 | 0.78 | AKR1B1 (0.42) | THRBTHRAF10AKR1B1 | |
| SCHEMBL9007582 | 0.76 | KMT2A (0.40) | THRBKMT2ATHRAAKR1B1ALDH1A1 | |
| SCHEMBL8829522 | 0.74 | ALOX5 (0.45) | NQO1CYP1A2CYP2A6CYP2D6 | |
| SCHEMBL12457724 | 0.73 | LMNA (0.48) | NQO1MAPTPOLBL3MBTL1KMT2A | |
| SCHEMBL9007535 | 0.72 | LDHA (0.32) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL15352237 | 0.69 | CYP1A2 (0.48) | THRBMEN1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL10392245 | 0.69 | CYP1A2 (0.48) | THRBMAPTMEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |