Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007515 | 0.95 | KMT2A (0.39) | KMT2ATHRATHRBKDM4ETDP1 | |
| SCHEMBL9007498 | 0.84 | PTPN7 (0.50) | KMT2ATHRATHRBPTPN1PTPN7 | |
| SCHEMBL9007551 | 0.82 | WDR5 (0.35) | THRATHRBKDM4ETDP1ALDH1A1 | |
| SCHEMBL9007566 | 0.81 | AKR1B1 (0.42) | THRATHRBAKR1B1SLC22A12 | |
| SCHEMBL9007533 | 0.78 | PTPN7 (0.49) | KMT2AHPGDPTPN1PTPN7TSHR | |
| SCHEMBL9007525 | 0.78 | AKR1B1 (0.41) | THRATHRBAKR1B1SLC22A12 | |
| SCHEMBL9007553 | 0.76 | NQO1 (0.37) | KMT2ATHRATHRBALDH1A1AKR1B1 | |
| SCHEMBL9007535 | 0.72 | LDHA (0.32) | KMT2AKDM4EALDH1A1HPGDAKR1B1 | |
| SCHEMBL11740657 | 0.70 | AKR1B1 (0.60) | KMT2ATHRATHRBKDM4EALDH1A1 | |
| SCHEMBL8734287 | 0.69 | KMT2A (0.42) | KMT2ATHRATHRBKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | claimed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | claimed |
| US-5482968-A | ENZYME INHIBITORS, HYPOGLYCEMIC AGENTS AND VASCULAR AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5399588-A | Diabetes treatment | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |