Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.38 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.38 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.38 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.38 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9016490 | 1.00 | TDP1 (0.52) | TDP1LMNATSHRALDH1A1NT5E | |
| SCHEMBL13893105 | 0.84 | F3 (0.57) | TDP1LMNATSHRALDH1A1NT5E | |
| SCHEMBL10458770 | 0.82 | TDP1 (0.53) | TDP1LMNATSHRALDH1A1NT5E | |
| SCHEMBL8751739 | 0.82 | HCAR2 (0.59) | TDP1LMNATSHRALDH1A1NPC1 | |
| SCHEMBL8751736 | 0.82 | HCAR2 (0.59) | TDP1LMNATSHRALDH1A1NPC1 | |
| SCHEMBL10458771 | 0.82 | TDP1 (0.53) | TDP1LMNATSHRALDH1A1NT5E | |
| Fumaric Acid SCHEMBL28726406 | 0.81 | TDP1 (0.75) | TDP1LMNATSHRALDH1A1NT5E | |
| SCHEMBL18662488 | 0.81 | F3 (0.50) | LMNAALDH1A1MAOBSMN1; SMN2HDAC1 | |
| SCHEMBL11391935 | 0.81 | TDP1 (0.67) | TDP1LMNATSHRALDH1A1NT5E | |
| SCHEMBL11391960 | 0.81 | TDP1 (0.67) | TDP1LMNATSHRALDH1A1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357082-B1 | Silver halide photographic emulsions | FUJI PHOTO FILM CO LTD (JP) | 1996-12-11 | — | — | EP | disclosed |
| US-5032500-A | Adding sensitizing dye containing for inhibitor after grain formation and before ripening | FUJI PHOTO FILM CO., LTD. (JP) | 1991-07-16 | — | — | US | disclosed |
| US-4971889-A | Spectral sensitizing dye containnig a hydrazine residue | FUJI PHOTO FILM CO., LTD. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0357082-A2 | Silver halide photographic emulsions | FUJI PHOTO FILM CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |