Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 10/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693383 | 0.84 | TDP1 (0.49) | TDP1KDM4EALDH1A1HPGDPTGIR | |
| SCHEMBL8418748 | 0.78 | KMT2A (0.53) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8417285 | 0.78 | KMT2A (0.53) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8202557 | 0.77 | SLC6A9 (0.48) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8202181 | 0.77 | TSHR (0.48) | TDP1KDM4EMAPTPOLB | |
| SCHEMBL8420212 | 0.77 | ALDH1A1 (0.51) | TDP1KDM4EALDH1A1HPGDPTGIR | |
| SCHEMBL8202190 | 0.77 | MAPK1 (0.43) | TDP1KDM4EALDH1A1HPGDPTGIR | |
| SCHEMBL8206250 | 0.76 | MAPT (0.47) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8202179 | 0.75 | MTNR1A (0.54) | TDP1KDM4EALDH1A1HPGDPTGIR | |
| SCHEMBL8624608 | 0.75 | KDM4E (0.46) | TDP1KDM4EALDH1A1HPGDPTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834642-A1 | COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST | Rigshospitalet (DK) | 2015-02-11 | — | — | EP | claimed |
| WO-2013143548-A1 | COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST | RIGSHOSPITALET (DK) | 2013-10-03 | — | — | WO | claimed |
| EP-2622354-A1 | COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST | Rigshospitalet (DK) | 2013-08-07 | — | — | EP | claimed |
| EP-2563369-A2 | METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF | Thrombologic APS (DK) | 2013-03-06 | — | — | EP | claimed |
| WO-2012041334-A1 | COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST | RIGSHOSPITALET (DK) | 2012-04-05 | — | — | WO | claimed |
| WO-2011134478-A2 | METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF | THROMBOLOGIC APS (DK) | 2011-11-03 | — | — | WO | claimed |
| EP-2563369-A2 | METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF | Thrombologic APS (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134478-A2 | METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF | THROMBOLOGIC APS (DK) | 2011-11-03 | — | — | WO | disclosed |