Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 9/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 9/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018418 | 0.92 | CXCR2 (0.46) | CXCR1CXCR2GABRA5EPHX2 | |
| SCHEMBL9018410 | 0.90 | P4HTM (0.47) | GABRA5EPHX2OPRM1OPRD1 | |
| SCHEMBL9018172 | 0.89 | MMP8 (0.47) | OPRM1OPRD1 | |
| SCHEMBL9018316 | 0.88 | CXCR1 (0.45) | CXCR1CXCR2GABRA5EPHX2 | |
| SCHEMBL9018373 | 0.87 | CXCR2 (0.48) | CXCR1CXCR2GABRA5 | |
| SCHEMBL9139374 | 0.86 | P4HTM (0.44) | CXCR1CXCR2 | |
| SCHEMBL9018043 | 0.84 | GABRA5 (0.47) | GABRA5EPHX2OPRM1OPRD1 | |
| SCHEMBL9018441 | 0.83 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL9018368 | 0.83 | GABRA5 (0.46) | GABRA5EPHX2OPRM1OPRD1 | |
| SCHEMBL8867737 | 0.83 | P4HTM (0.40) | CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |