Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018476 | 0.93 | HTT (0.50) | HTTKMT2AALDH1A1HSD17B10GAA | |
| SCHEMBL9018374 | 0.91 | ALDH1A1 (0.49) | HTTKMT2AALDH1A1HSD17B10GAA | |
| SCHEMBL9018178 | 0.90 | ALDH1A1 (0.49) | HTTKMT2AALDH1A1HSD17B10GAA | |
| SCHEMBL9018193 | 0.90 | LMNA (0.53) | HTTKMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7862847 | 0.88 | ALDH1A1 (0.47) | HTTKMT2AALDH1A1HSD17B10GAA | |
| SCHEMBL7870547 | 0.86 | HTT (0.48) | HTTKMT2AALDH1A1HSD17B10GAA | |
| SCHEMBL9139277 | 0.85 | ALDH1A1 (0.51) | HTTKMT2AALDH1A1HSD17B10GAA | |
| SCHEMBL9018241 | 0.83 | LMNA (0.49) | HTTKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL9018118 | 0.82 | RAB9A (0.44) | HTTKMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL9139866 | 0.82 | P4HTM (0.61) | HTTKMT2AALDH1A1HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |