Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469602 | 0.85 | HRH4 (0.45) | HRH4HRH3 | |
| SCHEMBL902067 | 0.84 | MTOR (0.54) | HRH4HRH3HTR3A | |
| SCHEMBL902018 | 0.83 | NCF1 (0.52) | HRH4 | |
| SCHEMBL3154750 | 0.80 | HTR3A (0.66) | HRH4HRH3HTR3A | |
| SCHEMBL28635726 | 0.74 | HRH4 (0.69) | HRH4HRH3HTR3A | |
| SCHEMBL3169890 | 0.71 | HRH4 (0.65) | HRH4HRH3 | |
| SCHEMBL2169898 | 0.71 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL30488018 | 0.71 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL12469600 | 0.70 | KARS1 (0.45) | HRH3 | |
| SCHEMBL6618181 | 0.69 | NOS1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |