SCHEMBL9023409

SCHEMBL9023409

N#Cc1c(-c2ccc(Cl)c(Cl)c2)n(O)c2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 1/20 0.46
HTT P42858 2/20 0.44
POLB P06746 1/20 0.44
CYP11B2 P19099 3/20 0.39
MAOA P21397 2/20 0.38
MAOB P27338 1/20 0.38
EGFR P00533 1/20 0.36
SRC P12931 1/20 0.36
NRP1 O14786 1/20 0.36
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
KMT2A Q03164 2/20 0.36
LMNA P02545 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NCOA3 Q9Y6Q9 1/20 0.36
CYP11B1 P15538 1/20 0.36
MET P08581 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022740 0.81 MAOA (0.51) HTTCYP11B2MAOAMAOBEGFR
SCHEMBL9023051 0.78 PARP1 (0.42) HTTCYP11B2MAOAMAOBEGFR
SCHEMBL9022595 0.77 MAOA (0.52) CCR2HTTPOLBCYP11B2MAOA
SCHEMBL9019167 0.77 MAPK14 (0.40) HTTPOLBALDH1A1KDM4EMEN1
SCHEMBL9023138 0.75 CYP11B2 (0.51) HTTCYP11B2MAOAMAOBEGFR
SCHEMBL9022441 0.75 MAOA (0.54) HTTPOLBCYP11B2MAOAMAOB
SCHEMBL9022797 0.75 KIF11 (0.41) CYP11B2MAOAMAOBEGFRSRC
SCHEMBL9023294 0.75 MAOA (0.41) HTTCYP11B2MAOAMAOBEGFR
SCHEMBL9022603 0.75 CTSS (0.42) HTTCYP11B2MAOAMAOBALDH1A1
SCHEMBL9019133 0.74 MAPK14 (0.41) HTTPOLBMAOAMAOBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0470665-B1 1-Hydroxyindole fungicides EASTMAN KODAK CO (US) 1996-04-24 EP disclosed
US-5118695-A 1-HYDROXYINDOLE FUNGICIDES EASTMAN KODAK COMPANY (US) 1992-06-02 US disclosed
EP-0470665-A1 1-Hydroxyindole fungicides EASTMAN KODAK COMPANY (US) 1992-02-12 EP disclosed