Sugi Predict

Sugi Predict / Compounds / SCHEMBL902478

SCHEMBL902478

SCHEMBL902478

COC(=O)c1nc2ccnn2c(O)c1Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.39
▸ NOTUM Q6P988 1/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ PKM P14618 1/20 0.37
▸ RCE1 Q9Y256 1/20 0.37
▸ PDE4B Q07343 6/20 0.37
▸ PDE4D Q08499 6/20 0.37
▸ PDE4A P27815 5/20 0.37
▸ PDE4C Q08493 5/20 0.37
▸ RNASEH1 O60930 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ HAO1 Q9UJM8 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ KCNN3 Q9UGI6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15274730 0.91 PDE4D (0.46) KDM4EPDE4BPDE4DPDE4APDE4C
SCHEMBL902329 0.90 PDE4A (0.47) TSHRNOTUMKDM4EPDE4ARNASEH1
SCHEMBL902327 0.89 PYGL (0.35) TSHRPDE4BPDE4DPDE4APDE4C
SCHEMBL902369 0.88 PDE4B (0.40) PDE4BPDE4DPDE4APDE4CALDH1A1
SCHEMBL901506 0.88 RNASEH1 (0.38) TSHRPDE4BPDE4DPDE4APDE4C
SCHEMBL902587 0.87 RNASEH1 (0.46) TSHRPDE4BPDE4DPDE4APDE4C
SCHEMBL902606 0.87 SLC6A3 (0.35) TSHRPDE4BPDE4DPDE4APDE4C
SCHEMBL902616 0.86 KCNN3 (0.46) KDM4EPDE4BPDE4DPDE4APDE4C
SCHEMBL901794 0.86 RNASEH1 (0.37) TSHRPDE4BPDE4DPDE4APDE4C
SCHEMBL902640 0.83 ALDH1A1 (0.52) KDM4EPDE4AALDH1A1HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 — — US disclosed
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 — — US disclosed
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LIMITED (GB) 2013-09-26 — — US disclosed
EP-2621928-A1 7-HYDROXY-PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS Proximagen Limited (GB) 2013-08-07 — — EP disclosed
WO-2012041817-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS PROXIMAGEN LTD (GB) 2012-04-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130252951-A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS CCR2, CCR5, CCR1 TSHR 531/4885NOTUM 4771/4885KDM4E 4265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.