Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695714 | 0.90 | CALM1 (0.42) | CALM1PTPN1HTR2APLA2G10PLA2G2A | |
| SCHEMBL371748 | 0.77 | CALM1 (0.46) | CALM1PTPN1HTR2ALTB4RBCL2 | |
| SCHEMBL20522534 | 0.76 | CALM1 (0.41) | CALM1PTPN1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL6947065 | 0.75 | ADRA1D (0.46) | CALM1PTPN1SMN1; SMN2ALOX5USP2 | |
| SCHEMBL5109182 | 0.72 | TSHR (0.43) | CALM1PTPN1PLA2G10PLA2G2ALTB4R | |
| SCHEMBL11394536 | 0.72 | HNF4A (0.47) | PTPN1PLA2G10PLA2G2ALTB4RUSP2 | |
| SCHEMBL21300544 | 0.72 | — | — | |
| SCHEMBL15055602 | 0.71 | KEAP1 (0.56) | CALM1PTPN1USP2ALDH1A1MAPT | |
| SCHEMBL28408319 | 0.71 | SLC6A2 (0.39) | CALM1PTPN1LTB4RTAAR1USP2 | |
| SCHEMBL10897516 | 0.71 | CALM1 (0.39) | CALM1PTPN1PLA2G10PLA2G2ALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100500672-C | N1, N3-disubstituted thieno [3,2-e] [2,1,3] thiadiazin-2, 2, 4-triketone derivatives and their applications | UNIV SHANDONG (CN) | 2009-06-17 | — | — | CN | disclosed |
| CN-1837215-A | N1,N3-disubstituted thieno[3,2-e][2,1,3] thiadiazine-2,2,4-triones derivatives and use thereof | UNIV SHANDONG (CN) | 2006-09-27 | — | — | CN | disclosed |
| EP-0667855-A4 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| EP-0667855-A1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011342-A1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1994-05-26 | — | — | WO | disclosed |