Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025606 | 0.79 | MGAM (0.39) | — | |
| SCHEMBL9219005 | 0.79 | GPR84 (0.36) | MEN1KMT2ACYP1A2KDM4E | |
| SCHEMBL9026660 | 0.76 | MAPT (0.35) | MEN1KMT2ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL9026002 | 0.72 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP3A4 | |
| SCHEMBL3983731 | 0.69 | SLC6A2 (0.37) | CYP3A4TSHRCYP2A6 | |
| SCHEMBL9030876 | 0.68 | NPBWR1 (0.34) | NPC1RAB9AMEN1PKMKMT2A | |
| SCHEMBL9025465 | 0.68 | CCR2 (0.34) | NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9025568 | 0.68 | METAP2 (0.39) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL9210152 | 0.68 | GPR84 (0.32) | L3MBTL1 | |
| SCHEMBL9025431 | 0.68 | MEN1 (0.39) | MEN1KMT2ASMN1; SMN2L3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |