Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025560 | 0.86 | METAP2 (0.40) | TSHRPOLBALDH1A1HTTMAPT | |
| SCHEMBL9032006 | 0.83 | CYP1A2 (0.36) | POLBHTTMAPTCYP1A2ATM | |
| SCHEMBL9026425 | 0.81 | TSHR (0.35) | TSHRHPGDHTR2CHTR2BHTR2A | |
| SCHEMBL9025461 | 0.80 | TP53 (0.35) | TSHRHPGDHTR2APOLBLMNA | |
| SCHEMBL9025423 | 0.79 | HSD17B10 (0.34) | TSHRHPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL9025676 | 0.74 | ACLY (0.41) | TSHRLMNAHTTMAPTMAPK1 | |
| SCHEMBL9025102 | 0.73 | MAPK1 (0.37) | TSHRPOLBLMNAHTTMAPT | |
| SCHEMBL9026853 | 0.73 | GAA (0.45) | TSHRHPGDPOLBLMNAALDH1A1 | |
| SCHEMBL9025513 | 0.73 | ALDH1A1 (0.50) | TSHRHPGDPOLBLMNAALDH1A1 | |
| SCHEMBL9026655 | 0.72 | GLA (0.36) | TSHRHTR2CHTR2BHTR2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |