Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | MAP2 | P11137 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025560 | 0.86 | METAP2 (0.40) | MAPTMETAP2SHMT2NPC1KMT2A | |
| SCHEMBL9026027 | 0.83 | TSHR (0.35) | CYP1A2MAPTATMPOLBHTT | |
| SCHEMBL9026534 | 0.82 | SLC9A1 (0.35) | CYP1A2MAPTCYP2C9CYP2C19TSPO | |
| SCHEMBL9025461 | 0.80 | TP53 (0.35) | CYP1A2MAPTNPC1KMT2AMEN1 | |
| SCHEMBL9025423 | 0.79 | HSD17B10 (0.34) | CYP1A2MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL9025676 | 0.74 | ACLY (0.41) | MAPTSHMT2NPC1KMT2AMEN1 | |
| SCHEMBL9026853 | 0.73 | GAA (0.45) | CYP1A2MAPTNPC1KMT2AMEN1 | |
| SCHEMBL9025513 | 0.73 | ALDH1A1 (0.50) | MAPTMETAP2KMT2AMEN1POLB | |
| SCHEMBL9026655 | 0.72 | GLA (0.36) | MAPTSHMT2KMT2AMEN1POLB | |
| SCHEMBL9024891 | 0.72 | NQO1 (0.37) | MAPTNPC1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |