Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032013 | 0.88 | MAPT (0.37) | CYP17A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9025511 | 0.82 | KDM4E (0.38) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9026853 | 0.78 | GAA (0.45) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9025513 | 0.78 | ALDH1A1 (0.50) | MAPTKDM4EHSD17B10ALDH1A1PDGFRB | |
| SCHEMBL9025554 | 0.77 | MAPK14 (0.39) | MAPTKDM4EMAPK1ALDH1A1ABCB1 | |
| SCHEMBL9024891 | 0.77 | NQO1 (0.37) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9025087 | 0.77 | ALDH1A1 (0.39) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL9026004 | 0.77 | NQO1 (0.37) | MAPTALDH1A1GAA | |
| SCHEMBL9216015 | 0.77 | NQO1 (0.37) | MAPTALDH1A1PDGFRBGAA | |
| SCHEMBL9025560 | 0.77 | METAP2 (0.40) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |