Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026327 | 0.88 | CYP11B2 (0.47) | MAPTSMN1; SMN2NPC1TLR8TLR7 | |
| SCHEMBL9025511 | 0.84 | KDM4E (0.38) | MAPTSMN1; SMN2NPC1ABCB1ABCG2 | |
| SCHEMBL9025513 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL9026853 | 0.81 | GAA (0.45) | MAPTSMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL9026004 | 0.80 | NQO1 (0.37) | MAPTALDH1A1GAATSHRNQO1 | |
| SCHEMBL9025087 | 0.80 | ALDH1A1 (0.39) | MAPTSMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL9024891 | 0.80 | NQO1 (0.37) | MAPTSMN1; SMN2NPC1ALDH1A1KDM4E | |
| SCHEMBL9216015 | 0.80 | NQO1 (0.37) | MAPTALDH1A1GAATSHRPDGFRB | |
| SCHEMBL9025560 | 0.80 | METAP2 (0.40) | MAPTSMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL9026462 | 0.77 | LTA4H (0.40) | MAPTSMN1; SMN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |