Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032013 | 0.84 | MAPT (0.37) | KDM4ESMN1; SMN2MAPTNPC1ALDH1A1 | |
| SCHEMBL9026327 | 0.82 | CYP11B2 (0.47) | KDM4ESMN1; SMN2MAPTNPC1MEN1 | |
| SCHEMBL9025513 | 0.79 | ALDH1A1 (0.50) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9026853 | 0.79 | GAA (0.45) | KDM4ESMN1; SMN2MAPTHTTNPC1 | |
| SCHEMBL9216015 | 0.78 | NQO1 (0.37) | MAPTALDH1A1GAA | |
| SCHEMBL9024891 | 0.78 | NQO1 (0.37) | KDM4ESMN1; SMN2MAPTHTTNPC1 | |
| SCHEMBL9026004 | 0.78 | NQO1 (0.37) | MAPTALDH1A1PKMGAA | |
| SCHEMBL9025560 | 0.78 | METAP2 (0.40) | SMN1; SMN2MAPTHTTNPC1MEN1 | |
| SCHEMBL9026462 | 0.75 | LTA4H (0.40) | KDM4ESMN1; SMN2MAPTL3MBTL1HTT | |
| SCHEMBL9025502 | 0.74 | PDE7A (0.37) | KDM4EMAPTL3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |