SCHEMBL903532

SCHEMBL903532

Oc1cc(Cl)ccc1-c1[nH]c2ccc(I)cc2c1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.38
CCNB2 O95067 1/20 0.37
CDK1 P06493 1/20 0.37
CCNB1 P14635 1/20 0.37
FLT3 P36888 1/20 0.37
GSK3A P49840 1/20 0.37
GSK3B P49841 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
CCNB3 Q8WWL7 1/20 0.37
CCNT1 O60563 1/20 0.37
CCNE1 P24864 1/20 0.37
CDK2 P24941 1/20 0.37
CDK9 P50750 1/20 0.37
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL903535 0.83 MGLL (0.46) DAOCCNB2CDK1CCNB1GSK3A
SCHEMBL903416 0.81 HTR2A (0.45) DAOCCNB2CDK1CCNB1GSK3B
SCHEMBL903542 0.80 ALOX5 (0.48) CCNB2CDK1CCNB1FLT3GSK3A
SCHEMBL903529 0.72 AR (0.50) CCNB2CDK1CCNB1FLT3GSK3A
SCHEMBL903527 0.70 ALDH1A1 (0.46) DAOALDH1A1CYP3A4TSHRHSD17B10
SCHEMBL903534 0.69 ALOX5 (0.53) CCNB2CDK1CCNB1GSK3AGSK3B
SCHEMBL15889343 0.68 CCNE1 (0.43) DAOCDK1CCNB1CCNT1CCNE1
SCHEMBL10215057 0.67 KIF11 (0.37) DAOCCNB2CDK1CCNB1GSK3B
SCHEMBL29090072 0.66 CA1 (0.44) CCNB2CDK1CCNB1GSK3AGSK3B
SCHEMBL903788 0.66 HTR2A (0.46) DAOCCNB2CDK1CCNB1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012041014-A1 TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed
WO-2012040923-A1 TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed