Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101052 | 0.84 | CYP1A2 (0.39) | CYP2A6CYP1A2ALDH1A1GAAMAPT | |
| SCHEMBL29529322 | 0.77 | ALDH1A1 (0.37) | CYP1A2ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL1092033 | 0.77 | ALDH1A1 (0.37) | CYP1A2ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL1611847 | 0.72 | AHR (0.48) | CYP2A6CYP1A2ALDH1A1GAAMAPT | |
| SCHEMBL1609847 | 0.72 | AHR (0.48) | CYP2A6CYP1A2ALDH1A1GAAMAPT | |
| SCHEMBL15845332 | 0.72 | — | — | |
| SCHEMBL24690433 | 0.72 | CYP1A2 (0.33) | CYP2A6CYP1A2ALDH1A1GAAMAPT | |
| SCHEMBL17288670 | 0.70 | ACHE (0.33) | CYP2A6CYP1A2ALDH1A1GAAMAPT | |
| SCHEMBL12482146 | 0.70 | ALDH1A1 (0.39) | ALDH1A1GAAMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL6917418 | 0.69 | CYP1A2 (0.31) | CYP2A6CYP1A2ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191484-B1 | PYRAZOLOPYRIDINE DERIVATIVES AND THEIR USE IN THERAPY | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH (DE) | 2024-06-12 | — | — | EP | disclosed |
| EP-4159736-A1 | NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Longwood Biopharmaceuticals Co., Ltd. (CN) | 2023-04-05 | — | — | EP | disclosed |
| EP-3473621-A1 | METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE | Daewoong Pharmaceutical Co., Ltd. (KR) | 2019-04-24 | — | — | EP | disclosed |
| US-10138242-B2 | Pyrazolopyridine derivatives and their use in therapy | HELMHOLTZ ZENTRUM MUENCHEN—DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (DE) | 2018-11-27 | — | — | US | disclosed |
| US-20180186789-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND THEIR USE IN THERAPY | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH (DE) | 2018-07-05 | — | — | US | disclosed |
| WO-2017217792-A1 | METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE | 주식회사 대웅제약 | 2017-12-21 | — | — | WO | disclosed |
| US-20160222047-A1 | C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHODS THEREOF, AND MEDICAL APPLICATIONS THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-08-04 | — | — | US | disclosed |
| US-9371303-B2 | Diphenylmethane derivatives as SGLT2 inhibitors | GREEN CROSS CORPORATION (KR) | 2016-06-21 | — | — | US | disclosed |
| EP-2993174-A1 | Pyrazolopyridine derivatives and their use in therapy | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH (DE) | 2016-03-09 | — | — | EP | disclosed |
| US-20150152075-A1 | NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS | GREEN CROSS CORPORATION (KR) | 2015-06-04 | — | — | US | disclosed |
| US-20110184033-A1 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110184033-A1 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-28 | — | — | US | disclosed |
| WO-2010077589-A2 | STAT3 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANSFER (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100168418-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-20100168418-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2010-07-01 | — | — | US | disclosed |
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20080139768-A1 | Copolymer Having Cyclic Ether Structure in Main Chain, Optical Member Comprising the Copolymer, and Method of Producing the Same | FUJIFILM CORPORATION (JP) | 2008-06-12 | — | — | US | disclosed |
| US-20080139768-A1 | Copolymer Having Cyclic Ether Structure in Main Chain, Optical Member Comprising the Copolymer, and Method of Producing the Same | FUJIFILM CORPORATION (JP) | 2008-06-12 | — | — | US | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168418-A1 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF | ROS1, NOX1, ARG1 | CYP2A6 2749/4885CYP1A2 1260/4885ALDH1A1 2925/4885 |
| US-20160222047-A1 | C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHODS THEREOF, AND MEDICAL APPLICATIONS THEREOF | SLC5A1, SLC5A2, UGGT1 | CYP2A6 634/4885CYP1A2 397/4885ALDH1A1 965/4885 |
| US-20150152075-A1 | NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS | SLC5A2, SLC5A1, SLC2A8 | CYP2A6 531/4885CYP1A2 811/4885ALDH1A1 1076/4885 |
| US-20110184033-A1 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same | DRD3, HTR3C, HTR3A | CYP2A6 1059/4885CYP1A2 1924/4885ALDH1A1 2290/4885 |
| US-20180186789-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND THEIR USE IN THERAPY | TPP1, PRDX5, TPMT | CYP2A6 2253/4885CYP1A2 390/4885ALDH1A1 1527/4885 |
| US-10138242-B2 | Pyrazolopyridine derivatives and their use in therapy | TPP1, PRDX5, TPMT | CYP2A6 2253/4885CYP1A2 390/4885ALDH1A1 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.