Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9040448 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2NPSR1LMNAALDH1A1PPARG | |
| SCHEMBL9040948 | 0.88 | L3MBTL1 (0.55) | SMN1; SMN2NPSR1LMNAALDH1A1PPARG | |
| SCHEMBL9040518 | 0.88 | MMP7 (0.53) | SMN1; SMN2NPSR1LMNAALDH1A1PPARG | |
| SCHEMBL9044249 | 0.87 | PTGDR2 (0.59) | SMN1; SMN2NPSR1LMNAALDH1A1PPARG | |
| SCHEMBL9040689 | 0.86 | TNF (0.59) | PPARGAGTR1AGTR2 | |
| SCHEMBL9041947 | 0.86 | PPARG (0.51) | SMN1; SMN2LMNAALDH1A1PPARGL3MBTL1 | |
| SCHEMBL9045081 | 0.86 | PPARG (0.55) | PPARGAGTR1AGTR2 | |
| SCHEMBL9040403 | 0.85 | PPARG (0.50) | SMN1; SMN2LMNAALDH1A1PPARGL3MBTL1 | |
| SCHEMBL9042383 | 0.84 | PPARG (0.60) | LMNAPPARGL3MBTL1HTTTSHR | |
| SCHEMBL9040956 | 0.84 | ALDH1A1 (0.61) | SMN1; SMN2NPSR1LMNAALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |