Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30249612 | 1.00 | ABL1 (0.59) | ABL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7447640 | 0.86 | ABL1 (0.56) | ABL1ALDH1A1KDM4ESMN1; SMN2FLT1 | |
| SCHEMBL2079618 | 0.85 | NOS2 (0.60) | ABL1ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL4043568 | 0.83 | ALDH1A1 (0.67) | ABL1ALDH1A1KDM4ESMN1; SMN2FLT1 | |
| SCHEMBL8129402 | 0.81 | ABL1 (0.54) | ABL1ALDH1A1KDM4ESMN1; SMN2FLT1 | |
| Hydrochloric Acid SCHEMBL4046791 | 0.81 | ALDH1A1 (0.65) | ABL1ALDH1A1KDM4ESMN1; SMN2FLT1 | |
| SCHEMBL9559750 | 0.81 | HSP90AB1 (0.48) | ABL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL29712843 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL1144066 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL17483639 | 0.80 | ABL1 (0.53) | ABL1ALDH1A1KDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101228142-A | Intermediate compounds for the synthesis of pharmaceutical preparations, and process for their preparation | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-07-23 | — | — | CN | claimed |
| US-20220162209-A1 | SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2022-05-26 | — | — | US | disclosed |
| CN-109843322-A | The inhibitor and its application method of indole amine 2,3-dioxygenase | 百时美施贵宝公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-106488910-A | Inhibitors of kras g12c | 亚瑞克西斯制药公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-105408320-A | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer | BOSTON BIOMEDICAL INC | 2016-03-16 | — | — | CN | disclosed |
| CN-104768947-A | [ 3-heteroaryl-2-trifluoromethyl-propyl ] -piperidin-1-yl or-morpholin-4-yl compounds as TRPA1 antagonists for the treatment of respiratory diseases | HOFFMANN LA ROCHE | 2015-07-08 | — | — | CN | disclosed |
| CN-102924458-B | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC | 2014-11-05 | — | — | CN | disclosed |
| CN-103476754-A | Adamantyl compounds | HOFFMANN LA ROCHE | 2013-12-25 | — | — | CN | disclosed |
| CN-102924458-A | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC | 2013-02-13 | — | — | CN | disclosed |
| CN-102459195-A | Substituted 1-alkylcinnolin-4 (1H) -one derivatives, preparation and therapeutic use thereof | SANOFI AVENTIS | 2012-05-16 | — | — | CN | disclosed |
| CN-102120741-A | Production method of an optically active compound | MITSUBISHI TANABE PHARMA CORP | 2011-07-13 | — | — | CN | disclosed |
| CN-102050820-A | Preparation method of compound with optical activity | MITSUBISHI TANABE PHARMA CORP | 2011-05-11 | — | — | CN | disclosed |
| US-20100228026-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-09-09 | — | — | US | disclosed |
| CN-101228142-A | Intermediate compounds for the synthesis of pharmaceutical preparations, and process for their preparation | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-07-23 | — | — | CN | disclosed |
| CN-1960993-A | 6, 6-bicyclic substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC (US) | 2007-05-09 | — | — | CN | disclosed |
| EP-0471358-B1 | Fluoroethylcamptothecin derivatives | KYORIN SEIYAKU KK (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0325247-B1 | CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARING SAME | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1993-05-19 | — | — | EP | disclosed |
| EP-0471358-A1 | Fluoroethylcamptothecin derivatives | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-02-19 | — | — | EP | disclosed |
| US-5061800-A | ANTITUMOR AGENTS | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1991-10-29 | — | — | US | disclosed |
| EP-0325247-A1 | Camptothecin derivatives and process for preparing same | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1989-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220162209-A1 | SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | ADSL, SLC35B2, ADORA1 | ABL1 1523/4885ALDH1A1 136/4885KDM4E 4057/4885 |
| US-20100228026-A1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | REN, AGTR2, AGTR1 | ABL1 2939/4885ALDH1A1 617/4885KDM4E 3644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.