Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11033678 | 0.85 | HTT (0.49) | HTTALOX15TSHRGSK3BCYP2C9 | |
| SCHEMBL9352397 | 0.85 | MMP2 (0.48) | HTTALOX15TSHRGSK3BPPARG | |
| SCHEMBL27807280 | 0.84 | HTT (0.45) | HTTALOX15TSHRGSK3BEPHX2 | |
| SCHEMBL16553310 | 0.82 | LMNA (0.59) | HTTALOX15TSHRCYP2C9CYP2C19 | |
| SCHEMBL2289091 | 0.82 | ALDH1A1 (0.50) | HTTGSK3BPOLBCES2CES1 | |
| SCHEMBL9356173 | 0.82 | MMP2 (0.51) | HTTALOX15TSHRGSK3BPPARG | |
| SCHEMBL442090 | 0.82 | MDM2 (0.59) | HTTTSHRGSK3BCES2CES1 | |
| SCHEMBL342966 | 0.81 | GSK3B (0.48) | HTTGSK3BPOLBCES2CES1 | |
| SCHEMBL5509922 | 0.81 | CYP2C9 (0.53) | ALOX15TSHRGSK3BCYP2C9CYP2C19 | |
| SCHEMBL7229416 | 0.81 | TPMT (0.48) | HTTMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238633-B2 | Methods for treating diabetic complications with carbamoyloxy arylalkanoyl arylpiperazine compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2016-01-19 | — | — | US | disclosed |
| US-8901116-B2 | Method for treating pain, anxiety or depression using carbamoyloxy alkanoyl piperazine compound | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-12-02 | — | — | US | disclosed |
| US-20140243352-A1 | METHODS FOR TREATING DIABETIC COMPLICATIONS WITH CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUNDS | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-08-28 | — | — | US | disclosed |
| US-20140088095-A1 | METHOD FOR TREATING PAIN, ANXIETY OR DEPRESSION USING CARBAMOYLOXY ALKANOYL PIPERAZINE COMPOUND | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-03-27 | — | — | US | disclosed |
| US-8648083-B2 | Method of treating diabetic hyperlipidemia or hyperlipidemia with carbamoyloxy arylalkanoyl arylpiperazine compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-02-11 | — | — | US | disclosed |
| US-8541409-B2 | Carbamoyloxy arylalkanoyl arylpiperazine analgesics | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-09-24 | — | — | US | disclosed |
| US-20130131081-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-05-23 | — | — | US | disclosed |
| EP-2590650-A2 | PHARMACEUTICAL COMPOSITIONS INCLUDING CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND | SK Biopharmaceuticals Co., Ltd. (KR) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012005536-A2 | PHARMACEUTICAL COMPOSITIONS INCLUDING CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2012-01-12 | — | — | WO | disclosed |
| EP-2155736-B1 | NOVEL CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK HOLDINGS CO LTD (KR) | 2011-12-21 | — | — | EP | disclosed |
| US-7101873-B2 | Pyrimidinedione derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2006-09-05 | — | — | US | disclosed |
| US-20060194799-A1 | Novel pyrimidinedione derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2006-08-31 | — | — | US | disclosed |
| EP-0742211-B1 | PYRIDAZINONE DERIVATIVES | NISSAN CHEMICAL IND LTD (JP) | 2000-05-10 | — | — | EP | disclosed |
| US-5856327-A | INHIBITING PLATELET AGGREGATION | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1999-01-05 | — | — | US | disclosed |
| US-5750523-A | INHIBITING PLATELET AGGREGATION | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0742211-A1 | PYRIDAZINONE DERIVATIVE | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0412933-B1 | Coating compositions | CIBA GEIGY AG (CH) | 1994-09-14 | — | — | EP | disclosed |
| US-5183842-A | Mixture of ketoacid and amine with film-forming binder, curing | CIBA-GEIGY CORPORATION (US) | 1993-02-02 | — | — | US | disclosed |
| US-5128396-A | Corrosion inhibiting primers on metallic substrates | CIBA-GEIGY CORPORATION (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0412933-A1 | Coating compositions | CIBA-GEIGY AG (CH) | 1991-02-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131081-A1 | PHARMACEUTICAL COMPOSITIONS INCLUDING CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND | LIPG, CETP, GPR119 | HTT 1164/4885ALOX15 46/4885TSHR 3750/4885 |
| US-20060194799-A1 | Novel pyrimidinedione derivatives | TYMS, TYMP, DPYD | HTT 3239/4885ALOX15 1142/4885TSHR 4039/4885 |
| US-20140088095-A1 | METHOD FOR TREATING PAIN, ANXIETY OR DEPRESSION USING CARBAMOYLOXY ALKANOYL PIPERAZINE COMPOUND | HTR5A, OPRL1, HDAC3 | HTT 665/4885ALOX15 143/4885TSHR 2865/4885 |
| US-20140243352-A1 | METHODS FOR TREATING DIABETIC COMPLICATIONS WITH CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUNDS | LIPG, DPP7, IAPP | HTT 1248/4885ALOX15 15/4885TSHR 3120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.