Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046010 | 0.88 | ALB (0.45) | GPR52CES2CES1BCHEALB | |
| SCHEMBL9048247 | 0.84 | GPR52 (0.40) | GPR52SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL9045397 | 0.82 | GABRA1 (0.35) | GPR52KDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL9045394 | 0.82 | AKR1B1 (0.39) | KMT2ACES2CES1SMN1; SMN2CD38 | |
| SCHEMBL9046816 | 0.81 | KMT2A (0.41) | KMT2AGPR52CES2CES1BCHE | |
| SCHEMBL9047469 | 0.81 | CA2 (0.34) | GPR52SMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL9057953 | 0.79 | GABRA1 (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL9045988 | 0.76 | GABRA1 (0.34) | KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9046829 | 0.74 | EED (0.40) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9045669 | 0.74 | TAAR1 (0.58) | KMT2ASMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |