Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | NEK4 | P51957 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047365 | 0.88 | TSHR (0.46) | AKR1B1CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9048247 | 0.84 | GPR52 (0.40) | HPGDSMN1; SMN2 | |
| SCHEMBL9045397 | 0.82 | GABRA1 (0.35) | TSHRHTT | |
| SCHEMBL9045101 | 0.82 | KMT2A (0.39) | KMT2ACES2CES1SMN1; SMN2CD38 | |
| SCHEMBL9047503 | 0.81 | AKR1B1 (0.41) | AKR1B1CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9047469 | 0.81 | CA2 (0.34) | TSHRSMN1; SMN2 | |
| SCHEMBL9057953 | 0.79 | GABRA1 (0.41) | CYP3A4CYP1A2TSHRHPGDSMN1; SMN2 | |
| SCHEMBL9046887 | 0.77 | TAAR1 (0.39) | AKR1B1LIPGSMN1; SMN2HTTTAAR1 | |
| SCHEMBL9046020 | 0.76 | TAAR1 (0.36) | AKR1B1LIPGSMN1; SMN2TAAR1 | |
| SCHEMBL9045669 | 0.74 | TAAR1 (0.58) | KMT2ATSHRSMN1; SMN2HTTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |