Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257778 | 0.78 | PDE4A (0.46) | SMN1; SMN2 | |
| SCHEMBL17273305 | 0.77 | KMO (0.67) | IDO1MAP4K4KMOEGLN2NOTUM | |
| SCHEMBL29450669 | 0.77 | KMO (0.67) | IDO1MAP4K4KMOEGLN2NOTUM | |
| SCHEMBL22211542 | 0.76 | PTGS1 (0.45) | IDO1MAP4K4KMOALOX5EGLN2 | |
| SCHEMBL4452902 | 0.74 | ALOX5 (0.45) | IDO1ALOX5IKBKENOTUMNPC1 | |
| SCHEMBL9048672 | 0.74 | CYP1A2 (0.48) | MAP4K4NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL817554 | 0.74 | ALOX5 (0.65) | IDO1ALOX5NOTUMNPC1TP53 | |
| SCHEMBL31222672 | 0.74 | ALOX5 (0.65) | IDO1ALOX5NOTUMNPC1TP53 | |
| SCHEMBL9047230 | 0.73 | ALDH1A1 (0.51) | IDO1NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL4450693 | 0.73 | ALOX5 (0.48) | IDO1ALOX5IKBKENOTUMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |