Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046401 | 0.85 | TSHR (0.50) | AKR1B1CYP3A4ADRA2AKMT2ACYP2C9 | |
| SCHEMBL9045526 | 0.83 | BRPF1 (0.39) | CYP3A4KMT2ACYP2C9LMNAHSD17B10 | |
| SCHEMBL9045394 | 0.81 | AKR1B1 (0.39) | AKR1B1CYP3A4KMT2ACYP2C9CYP2C19 | |
| SCHEMBL9045271 | 0.81 | GABRA1 (0.37) | LMNAMAPTTSHRSMN1; SMN2HTT | |
| SCHEMBL9046816 | 0.81 | KMT2A (0.41) | KMT2AMEN1CES2CES1SMN1; SMN2 | |
| SCHEMBL3757556 | 0.78 | TAAR1 (0.54) | AKR1B1CYP3A4ADRA2AKMT2ACYP2C9 | |
| SCHEMBL9047582 | 0.78 | LMNA (0.50) | KMT2ALMNAMAPK1MAPTHPGD | |
| SCHEMBL9047730 | 0.78 | CA2 (0.35) | LMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL9056727 | 0.78 | GABRA1 (0.43) | CYP3A4KMT2ALMNAHIF1AHTR2C | |
| SCHEMBL9046154 | 0.75 | TAAR1 (0.42) | AKR1B1CYP3A4ADRA2AKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0664802-A1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1995-08-02 | — | — | EP | disclosed |