Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.47 |
| ▸ | RELA | Q04206 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851321 | 0.79 | HPGD (0.48) | GAANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9050232 | 0.79 | SMN1; SMN2 (0.63) | CYP1A2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9050448 | 0.78 | TRPV1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL880500 | 0.77 | GAA (0.76) | CYP1A2CYP2C19GAANPC1RAB9A | |
| SCHEMBL9581806 | 0.76 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL7325548 | 0.76 | SMN1; SMN2 (0.45) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7327986 | 0.76 | L3MBTL1 (0.47) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9050178 | 0.76 | KMT2A (0.52) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6227837 | 0.75 | GAA (0.68) | CYP1A2CYP2C19GAANPC1RAB9A | |
| Fumaric Acid SCHEMBL7334141 | 0.75 | HPGD (0.43) | GAANPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5496942-A | 5-HT3-RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |