Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851321 | 0.79 | HPGD (0.48) | SMN1; SMN2NPC1RAB9APOLBLMNA | |
| SCHEMBL9049386 | 0.79 | CYP1A2 (0.49) | SMN1; SMN2NPC1RAB9APOLBCYP1A2 | |
| SCHEMBL16286465 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL9050448 | 0.78 | TRPV1 (0.47) | SMN1; SMN2NPC1RAB9APOLBLMNA | |
| SCHEMBL7325548 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9APOLBLMNA | |
| SCHEMBL7327986 | 0.76 | L3MBTL1 (0.47) | SMN1; SMN2NPC1RAB9ATDP1LMNA | |
| Fumaric Acid SCHEMBL7334141 | 0.75 | HPGD (0.43) | SMN1; SMN2NPC1RAB9ALMNAMAPT | |
| Hydrochloric Acid SCHEMBL9050917 | 0.75 | HTR3A (0.39) | ADORA2AADORA1LMNAMAPT | |
| SCHEMBL5897586 | 0.74 | SMN1; SMN2 (0.84) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL7324842 | 0.74 | KDM4E (0.43) | TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5496942-A | 5-HT3-RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |