Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262202 | 0.76 | PGR (0.46) | PGRALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL11813866 | 0.72 | KDM4E (0.33) | HTTALDH1A1KDM4EATMBRD4 | |
| SCHEMBL5408306 | 0.70 | ALDH1A1 (0.37) | PGRTDP1HTTALDH1A1 | |
| SCHEMBL7837477 | 0.69 | TYMS (0.34) | PGRHTTALDH1A1BRD4TSHR | |
| SCHEMBL568994 | 0.69 | PGR (0.55) | PGRHTTALDH1A1KDM4EATM | |
| SCHEMBL3368781 | 0.69 | TSHR (0.42) | PGRHTTALDH1A1KDM4EBRD4 | |
| SCHEMBL1455080 | 0.69 | ALDH1A1 (0.41) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL4830158 | 0.68 | PGR (0.50) | PGRTDP1HTTALDH1A1KDM4E | |
| SCHEMBL17391093 | 0.66 | PGR (0.35) | PGRTDP1HTTALDH1A1KDM4E | |
| SCHEMBL3368868 | 0.65 | PGR (0.69) | PGRHTTALDH1A1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6009483-A | — | — | None | — | — | JP | disclosed |
| EP-0567953-B1 | Process for the preparation of substituted indanones | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5329049-A | Process for the preparation of substituted indanones | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-07-12 | — | — | US | disclosed |
| JP-H069483-A | PREPARATION OF SUBSTITUTED INDANONES | HOECHST AG | 1994-01-18 | — | — | JP | disclosed |
| EP-0567953-A1 | Process for the preparation of substituted indanones | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |