Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.57 |
| ▸ | CCKBR | P32239 | 3/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331379 | 0.92 | CHRM1 (0.62) | LMNAMEN1ALBKMT2AGABRA1 | |
| SCHEMBL21272248 | 0.87 | CHRM1 (0.74) | LMNAMEN1ALBKMT2AGABRA1 | |
| SCHEMBL7935883 | 0.87 | CHRM1 (0.74) | LMNAMEN1ALBKMT2AGABRA1 | |
| SCHEMBL11633050 | 0.86 | LMNA (0.79) | LMNAMEN1ALBKMT2ACHRM1 | |
| SCHEMBL19585356 | 0.85 | GABRA1 (0.77) | LMNAMEN1ALBKMT2AGABRA1 | |
| SCHEMBL19585355 | 0.85 | GABRA1 (0.77) | LMNAMEN1ALBKMT2AGABRA1 | |
| SCHEMBL10203612 | 0.84 | CCKBR (0.61) | LMNAMEN1ALBKMT2ACHRM1 | |
| SCHEMBL607124 | 0.80 | CCKBR (0.56) | LMNAMEN1ALBKMT2ACHRM1 | |
| SCHEMBL2268056 | 0.79 | CCKBR (0.55) | LMNAMEN1ALBKMT2ACHRM1 | |
| SCHEMBL606101 | 0.79 | CCKBR (0.55) | LMNAMEN1ALBKMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20090253686-A1 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-10-08 | — | — | US | disclosed |
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-11-27 | — | — | US | disclosed |
| WO-2007053193-A2 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070043033-A1 | Unsolvated benzodiazepine compositions and methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-02-22 | — | — | US | disclosed |
| US-5545568-A | ARRAY OF COMPOUNDS ON SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-08-13 | — | — | US | disclosed |
| US-5288514-A | Linking a protected 2-aminobenzophenone to a substrate; deprotecting and reacting with an amino acid; cyclization; removal from substrate; screening | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | BAX, BAD, GABRB3 | LMNA 2518/4885MEN1 4503/4885ALB 4455/4885 |
| US-20070043033-A1 | Unsolvated benzodiazepine compositions and methods | GABRA5, GABRA3, GABRA6 | LMNA 1390/4885MEN1 3952/4885ALB 2710/4885 |
| US-20090253686-A1 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | GABRA5, GABRA3, GABRA6 | LMNA 1390/4885MEN1 3952/4885ALB 2710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.