Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11904034 | 0.85 | ALDH1A1 (0.61) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8746687 | 0.82 | ALDH1A1 (0.64) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8811170 | 0.79 | MAPT (0.58) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL5657641 | 0.79 | MAPT (0.57) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL11427588 | 0.79 | MAPK1 (0.47) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL7297643 | 0.77 | MAPT (0.58) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9570633 | 0.77 | MAPT (0.58) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL907414 | 0.77 | HPGD (0.60) | MAPTALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL5105394 | 0.76 | CA2 (0.56) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8973697 | 0.76 | MAPT (0.54) | MAPTALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133099-B1 | Conjugated biological molecules and their preparation | POLYTHERICS LTD (GB) | 2017-04-19 | — | — | EP | disclosed |
| US-9439974-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2016-09-13 | — | — | US | disclosed |
| EP-2253330-B1 | Conjugated biological molecules and their preparation | POLYTHERICS LTD (GB) | 2015-08-19 | — | — | EP | disclosed |
| EP-2277550-B1 | Process for the preparation of conjugated biological molecules. | POLYTHERICS LTD (GB) | 2015-04-29 | — | — | EP | disclosed |
| US-20140369960-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | ABZENA (CAMBRIDGE) LIMITED (GB) | 2014-12-18 | — | — | US | disclosed |
| US-8816051-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2014-08-26 | — | — | US | disclosed |
| US-8470863-B2 | Derivatives and analogs of chroman as functionally selective ALPHA2C adrenoreceptor agonists | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110182855-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | POLYTHERICS LIMITED (GB) | 2011-07-28 | — | — | US | disclosed |
| US-7939630-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2011-05-10 | — | — | US | disclosed |
| EP-2277550-A1 | Conjugated biological molecules and their preparation | Polytherics Limited (GB) | 2011-01-26 | — | — | EP | disclosed |
| EP-2253330-A2 | Conjugated biological molecules and their preparation | Polytherics Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| US-20100168195-A1 | DERIVATIVES AND ANALOGS OF CHROMAN AS FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
| EP-2133099-A2 | Conjugated biological molecules and their preparation | Polytherics Limited (GB) | 2009-12-16 | — | — | EP | disclosed |
| US-20090298154-A1 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2009-12-03 | — | — | US | disclosed |
| US-7595292-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2009-09-29 | — | — | US | disclosed |
| EP-1648518-B1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | POLYTHERICS LTD (GB) | 2009-08-26 | — | — | EP | disclosed |
| US-20060210526-A1 | polyoxyethylene glycol-protein conjugate linked via linking group | ABZENA (CAMBRIDGE) LIMITED (GB) | 2006-09-21 | — | — | US | disclosed |
| EP-1648518-A2 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | Polytherics Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005007197-A2 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | POLYTHERICS LIMITED (GB) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140369960-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | F13B, F13A1, ZYX | MAPT 4472/4885ALDH1A1 3197/4885POLB 567/4885 |
| US-20110182855-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | F13B, ZYX, F13A1 | MAPT 4643/4885ALDH1A1 3013/4885POLB 308/4885 |
| US-20100168195-A1 | DERIVATIVES AND ANALOGS OF CHROMAN AS FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS | ADRA2C, ADRB2, ADRA2A | MAPT 3752/4885ALDH1A1 1551/4885POLB 4033/4885 |
| US-20090298154-A1 | Conjugated biological molecules and their preparation | F13B, ZYX, F13A1 | MAPT 4643/4885ALDH1A1 3013/4885POLB 308/4885 |
| US-20060210526-A1 | polyoxyethylene glycol-protein conjugate linked via linking group | F13A1, F13B, SSB | MAPT 4536/4885ALDH1A1 4140/4885POLB 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.