Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexane SCHEMBL9090961 | 0.89 | AGTR1 (0.45) | PTPN1AGTR1AGTR2PLK1PLK3 | |
| Hexane SCHEMBL9090041 | 0.87 | KMT2A (0.46) | PTPN1AGTR1AGTR2PLK1GAA | |
| Hexane SCHEMBL9371099 | 0.84 | AGTR1 (0.61) | PTPN1AGTR1AGTR2PLK1PLK3 | |
| Hexane SCHEMBL9089037 | 0.81 | MAPT (0.43) | AGTR1AGTR2L3MBTL1PSEN1PSEN2 | |
| SCHEMBL9090171 | 0.80 | AGTR1 (0.61) | PTPN1AGTR1AGTR2PLK1PLK3 | |
| SCHEMBL9090184 | 0.78 | PTPN1 (0.41) | PTPN1AGTR1AGTR2PLK1PLK3 | |
| Hexane SCHEMBL9091640 | 0.76 | MEN1 (0.51) | PTPN1AGTR1AGTR2PLK1PLK3 | |
| Water SCHEMBL9090942 | 0.75 | AGTR1 (0.71) | PTPN1AGTR1AGTR2PLK1PLK3 | |
| Hexane SCHEMBL9089999 | 0.74 | SORT1 (0.47) | AGTR1AGTR2PLK1PLK3PSEN1 | |
| Hexane SCHEMBL9088251 | 0.71 | RAB9A (0.39) | GAAPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571925-A | HORMONES INHIBITORS FOR HYPOTENSIVE AGENTS | ELI LILLY AND COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| US-5563278-A | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0438869-B1 | Improvements in and relating to angiotensin II antagonists | LILLY CO ELI (US) | 1994-12-14 | — | — | EP | disclosed |
| US-5312936-A | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| US-5073566-A | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1991-12-17 | — | — | US | disclosed |