Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | RECQL | P46063 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9095138 | 1.00 | ADRA2A (0.58) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL15631302 | 0.78 | ADRA1A (0.57) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL29374680 | 0.73 | ADRA2A (1.00) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL10430788 | 0.71 | LMNA (0.41) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL12958049 | 0.69 | KDM4E (0.53) | ADRA2AADRA2CADRA1AADRB1KDM4E | |
| SCHEMBL9089541 | 0.69 | ADRA1A (0.55) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL9089549 | 0.69 | ADRA1A (0.55) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL11851290 | 0.69 | ADRB2 (1.00) | ADRA2AADRA2CADRA1AADRB2ADRA2B | |
| SCHEMBL11406743 | 0.68 | GABRA1 (0.58) | ADRA2AADRA2CADRA1AADRB1KDM4E | |
| SCHEMBL27472717 | 0.68 | ADRA2A (0.55) | ADRA2AADRA2CADRA1AADRB2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527830-A | Drugs for the treatment of cardiac arrest and other shock states | THE OHIO STATE UNIVERSITY (US) | 1996-06-18 | — | — | US | claimed |
| US-5527830-A | Drugs for the treatment of cardiac arrest and other shock states | THE OHIO STATE UNIVERSITY (US) | 1996-06-18 | — | — | US | disclosed |