Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL96213 | 0.83 | CYP1A2 (0.43) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL9570945 | 0.83 | CA1 (0.33) | ALDH1A1 | |
| SCHEMBL9329818 | 0.77 | L3MBTL1 (0.47) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL9242790 | 0.74 | — | — | |
| SCHEMBL102469 | 0.74 | CYP1A2 (0.36) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL20237221 | 0.73 | C1R (0.35) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL910072 | 0.73 | ALDH1A1 (0.41) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL535572 | 0.73 | TAAR1 (0.41) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL6149211 | 0.73 | TSHR (0.48) | CYP1A2CYP2A6ALDH1A1TDP1MEN1 | |
| SCHEMBL10316768 | 0.70 | LMNA (0.41) | ALDH1A1TDP1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |
| WO-2015008234-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-01-22 | — | — | WO | disclosed |
| US-8426588-B2 | Phenylalanine derivatives | AJINOMOTO CO, INC. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-20120253041-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2012-10-04 | — | — | US | disclosed |
| US-8222405-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20110065918-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2011-03-17 | — | — | US | disclosed |
| EP-1288205-B1 | NOVEL PHENYLALANINE DERIVATIVES | AJINOMOTO KK (JP) | 2011-02-02 | — | — | EP | disclosed |
| US-7872125-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2011-01-18 | — | — | US | disclosed |
| EP-1477482-B1 | NOVEL PHENYLALANINE DERIVATIVE | AJINOMOTO KK (JP) | 2010-04-14 | — | — | EP | disclosed |
| US-7605165-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-7153963-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20060223836-A1 | New phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-10-05 | — | — | US | disclosed |
| US-20050101779-A1 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1477482-A1 | NOVEL PHENYLALANINE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2004-11-17 | — | — | EP | disclosed |
| EP-1288205-A1 | NOVEL PHENYLALANINE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223836-A1 | New phenylalanine derivatives | ITGB4, ITGA4, ITGAV | CYP1A2 4366/4885CYP2A6 3860/4885ALDH1A1 1310/4885 |
| US-20050101779-A1 | Phenylalanine derivatives | ITGB4, ITGA4, ITGB3 | CYP1A2 3906/4885CYP2A6 3498/4885ALDH1A1 987/4885 |
| US-20110065918-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, ITGA4, ITGAV | CYP1A2 4366/4885CYP2A6 3860/4885ALDH1A1 1310/4885 |
| US-20120253041-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, ITGA4, ITGAV | CYP1A2 4366/4885CYP2A6 3860/4885ALDH1A1 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.