Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100221 | 0.75 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL16897619 | 0.74 | AKR1B1 (0.35) | AKR1B1 | |
| SCHEMBL18192836 | 0.74 | BACE1 (0.33) | AKR1B1 | |
| SCHEMBL7479848 | 0.73 | HDAC3 (0.43) | P2RX7OPRL1HDAC3HDAC1HDAC2 | |
| SCHEMBL9252199 | 0.71 | KDM1A (0.42) | ALOX5 | |
| SCHEMBL18021960 | 0.70 | OPRM1 (0.51) | OPRL1HDAC4 | |
| SCHEMBL9458668 | 0.70 | CYP1A2 (0.34) | ALOX5 | |
| SCHEMBL9458422 | 0.69 | HTR1A (0.31) | ALOX5 | |
| SCHEMBL23228689 | 0.69 | DRD2 (0.40) | P2RX7OPRL1HDAC3HDAC1HDAC2 | |
| SCHEMBL18192959 | 0.69 | BACE1 (0.42) | P2RX7HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702680-A1 | 2-OXO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994029297-A1 | 2-OXO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |