Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 11/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12387047 | 0.85 | KMT2A (0.64) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL911203 | 0.83 | MEN1 (0.57) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL1147727 | 0.80 | MEN1 (0.57) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL1068265 | 0.80 | MEN1 (0.85) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL2318131 | 0.79 | MEN1 (0.68) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL3032465 | 0.78 | NR1H4 (0.62) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL1392660 | 0.78 | MEN1 (0.55) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL11100803 | 0.77 | NR1H4 (0.72) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL438314 | 0.77 | MEN1 (0.70) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL12869943 | 0.76 | NR1H4 (0.70) | MEN1KMT2AMAPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9700501-B2 | Use of indole compounds as a cosmetic | MERCK PATENT GMBH (DE) | 2017-07-11 | — | — | US | disclosed |
| US-9603784-B2 | Process for treating sol-gel capsules | MERCK PATENT GMBH (DE) | 2017-03-28 | — | — | US | disclosed |
| US-20130156834-A1 | PROCESS FOR TREATING SOL-GEL CAPSULES | MERCK PATENT GMBH (DE) | 2013-06-20 | — | — | US | disclosed |
| US-20130045174-A1 | USE OF INDOLE COMPOUNDS AS A COSMETIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-02-21 | — | — | US | disclosed |
| US-7906684-B2 | Antioxidants | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | disclosed |
| US-7867993-B2 | Preparation containing oxidized flavonoid derivatives | MERCK PATENT GMBH (DE) | 2011-01-11 | — | — | US | disclosed |
| US-20100034760-A1 | Method of Increasing the Tanning Effect of Self-tanning Substances | MERCK PATENT GMBH (DE) | 2010-02-11 | — | — | US | disclosed |
| US-20100028278-A1 | USE OF CHROMAN-4-ONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20090246158-A1 | ANTIOXIDANTS | MERCK PATENT GESELLSCHAFT (DE) | 2009-10-01 | — | — | US | disclosed |
| EP-1186288-B1 | Cosmetic and dermatologic sunscreen compositions containing asymmetrically substituted triazine derivatives and organosiloxanes | BEIERSDORF AG (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-20080319050-A1 | Preparation Containing Oxidized Flavonoid Derivatives | MERCK PATENT GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080171004-A1 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | MERCK PATENT GMBH (DE) | 2008-07-17 | — | — | US | disclosed |
| EP-1186288-A2 | Cosmetic and dermatologic sunscreen compositions containing asymmetrically substituted triazine derivatives and organosiloxanes | Beiersdorf AG (DE) | 2002-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090246158-A1 | ANTIOXIDANTS | LPO, GPX1, GPX4 | MEN1 2805/4885KMT2A 2864/4885MAPT 1568/4885 |
| US-20080171004-A1 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | HPD, HAAO, UGT1A6 | MEN1 2420/4885KMT2A 1522/4885MAPT 1111/4885 |
| US-20100034760-A1 | Method of Increasing the Tanning Effect of Self-tanning Substances | TYR, TES, SHBG | MEN1 3024/4885KMT2A 1703/4885MAPT 3028/4885 |
| US-20130156834-A1 | PROCESS FOR TREATING SOL-GEL CAPSULES | SUCLG1, TYR, PGA5 | MEN1 866/4885KMT2A 3032/4885MAPT 1808/4885 |
| US-20130045174-A1 | USE OF INDOLE COMPOUNDS AS A COSMETIC | IDO1, TYR, IDO2 | MEN1 710/4885KMT2A 215/4885MAPT 2353/4885 |
| US-20100028278-A1 | USE OF CHROMAN-4-ONE DERIVATIVES | COXFA4L2, TYR, XPA | MEN1 1523/4885KMT2A 3375/4885MAPT 2529/4885 |
| US-20080319050-A1 | Preparation Containing Oxidized Flavonoid Derivatives | NQO1, LPO, NDUFV2 | MEN1 3703/4885KMT2A 3071/4885MAPT 3078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.