Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL10775852 | 0.97 | MEN1 (0.53) | MEN1KMT2ALMNACA1CA4 | |
| Tromethamine SCHEMBL5710709 | 0.85 | LMNA (0.67) | MEN1KMT2ALMNABLMS1PR1 | |
| Tromethamine SCHEMBL194002 | 0.82 | LMNA (0.62) | MEN1KMT2ALMNAFFAR3BLM | |
| Tromethamine SCHEMBL19183294 | 0.82 | LMNA (0.62) | MEN1KMT2ALMNABLMS1PR1 | |
| Tromethamine SCHEMBL4581519 | 0.82 | LMNA (0.62) | MEN1KMT2ALMNAFFAR3BLM | |
| Tromethamine SCHEMBL7347818 | 0.82 | LMNA (0.62) | MEN1KMT2ALMNAFFAR3BLM | |
| Tromethamine SCHEMBL7100590 | 0.80 | LMNA (0.46) | MEN1KMT2ALMNACA1CA4 | |
| Tromethamine SCHEMBL15552130 | 0.78 | LMNA (0.56) | MEN1KMT2ALMNABLMS1PR1 | |
| Deanol SCHEMBL7564579 | 0.78 | CA1 (0.44) | MEN1KMT2ALMNACA1CA4 | |
| Tromethamine SCHEMBL22288065 | 0.77 | MEN1 (0.42) | MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170141242-A1 | ANTI-REFLECTIVE AND ANTI-SOILING COATINGS WITH SELF-CLEANING PROPERTIES | FIRST SOLAR, INC. | 2017-05-18 | — | — | US | disclosed |
| US-9461185-B2 | Anti-reflective and anti-soiling coatings with self-cleaning properties | Enki Technology, Inc. (US) | 2016-10-04 | — | — | US | disclosed |
| US-9376593-B2 | Multi-layer coatings | Enki Technology, Inc. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9353268-B2 | Anti-reflective and anti-soiling coatings for self-cleaning properties | Enki Technology, Inc. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160035912-A1 | ANTI-REFLECTIVE AND ANTI-SOILING COATINGS WITH SELF-CLEANING PROPERTIES | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2016-02-04 | — | — | US | disclosed |
| US-20160002498-A1 | MULTI-LAYER COATINGS | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2016-01-07 | — | — | US | disclosed |
| US-20150037570-A1 | ANTI-REFLECTIVE AND ANTI-SOILING COATINGS FOR SELF-CLEANING PROPERTIES | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2015-02-05 | — | — | US | disclosed |
| WO-1995011438-A1 | MODIFIED-RELEASE DOSAGE FORM DISSOLUTION CONTROL METHOD USING A SOLID REAGENT, AND SINGLE-DOSE SACHET CONTAINING SAID REAGENT | PIERRE FABRE MEDICAMENT (FR) | 1995-04-27 | — | — | WO | disclosed |