Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 3/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974421 | 0.78 | PTGS2 (0.43) | KIF11 | |
| SCHEMBL8974585 | 0.78 | KIF11 (0.46) | MAPTKIF11 | |
| SCHEMBL9117010 | 0.78 | KIF11 (0.39) | PTGES2NPC1RAB9AKIF11 | |
| SCHEMBL8974117 | 0.74 | PTGS2 (0.40) | — | |
| SCHEMBL8973879 | 0.74 | KIF11 (0.45) | GAAMAPTKIF11 | |
| SCHEMBL3476657 | 0.71 | POLB (0.61) | HSD11B1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8973781 | 0.67 | KIF11 (0.59) | MAPTKIF11 | |
| SCHEMBL8975759 | 0.67 | PTGS2 (0.50) | KIF11 | |
| SCHEMBL8973759 | 0.66 | POLB (0.41) | KIF11POLB | |
| SCHEMBL8973763 | 0.66 | POLB (0.41) | MAPTKIF11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |