Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119858 | 0.83 | HTR7 (0.51) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| SCHEMBL9119904 | 0.81 | HTR6 (0.46) | HTR1AHTR7HTR6HTR2AHTR5A | |
| SCHEMBL9119205 | 0.81 | ADRB1 (0.49) | HTR1AHTR7HTR6HTR3AHTR2A | |
| SCHEMBL2545151 | 0.71 | HTR6 (0.47) | HTR1AHTR7HTR6HTR2BHTR2A | |
| SCHEMBL9121582 | 0.68 | HTR7 (0.47) | HTR1AHTR7HTR6HTR3AHTR2B | |
| SCHEMBL8191985 | 0.67 | HTR1A (0.46) | HTR1AHTR7HTR6HTR3AHTR2B | |
| Hydrochloric Acid SCHEMBL6298232 | 0.67 | DYRK1A (0.47) | HTR6 | |
| Hydrochloric Acid SCHEMBL15937978 | 0.66 | LMNA (0.48) | HTR1AHTR7HTR6HTR3AHTR2B | |
| SCHEMBL233938 | 0.66 | KDR (0.53) | HTR1AHTR7HTR6HTR3AHTR2B | |
| SCHEMBL29557426 | 0.66 | KDR (0.53) | HTR1AHTR7HTR6HTR3AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189612-B1 | NEW PHARMACEUTICAL COMPOSITIONS HAVING A PSYCHOTROPIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-04 | — | — | EP | claimed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | claimed |
| US-5424313-A | Bibyclic heteroacrylpiperazine derivatives having psychotropic activity, and pharmaceutical compositions containing these derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-06-13 | — | — | US | disclosed |
| EP-0189612-B1 | NEW PHARMACEUTICAL COMPOSITIONS HAVING A PSYCHOTROPIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-04 | — | — | EP | disclosed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | disclosed |