Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 5/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119205 | 0.83 | ADRB1 (0.49) | HTR7ADRB1HTR3AHTR3EHTR3B | |
| SCHEMBL9119128 | 0.83 | HTR1A (0.43) | HTR7ADRB1HTR3AHTR3EHTR3B | |
| SCHEMBL9119904 | 0.83 | HTR6 (0.46) | HTR7ADRB1HTR1A | |
| SCHEMBL1477092 | 0.74 | ADRB1 (0.47) | HTR7ADRB1 | |
| SCHEMBL2545151 | 0.72 | HTR6 (0.47) | HTR7ADRB1HTR1A | |
| SCHEMBL31051724 | 0.69 | DRD2 (0.67) | HTR7ADRB1HTR3AHTR3EHTR3B | |
| SCHEMBL22542051 | 0.68 | ADRB1 (0.70) | HTR7ADRB1HTR3AHTR3EHTR3B | |
| SCHEMBL14904817 | 0.68 | HTR7 (1.00) | HTR7ADRB1HTR3AHTR1A | |
| Hydrochloric Acid SCHEMBL27907732 | 0.67 | ADRB1 (0.68) | HTR7ADRB1HTR3AHTR3EHTR3B | |
| SCHEMBL255197 | 0.67 | HTR3A (0.67) | HTR7ADRB1HTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189612-B1 | NEW PHARMACEUTICAL COMPOSITIONS HAVING A PSYCHOTROPIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-04 | — | — | EP | claimed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | claimed |
| US-5424313-A | Bibyclic heteroacrylpiperazine derivatives having psychotropic activity, and pharmaceutical compositions containing these derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-06-13 | — | — | US | disclosed |
| EP-0189612-B1 | NEW PHARMACEUTICAL COMPOSITIONS HAVING A PSYCHOTROPIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-04 | — | — | EP | disclosed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | disclosed |