Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91267 | 0.91 | LMNA (0.43) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL78505 | 0.81 | KDM4E (0.41) | LMNAMAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL91273 | 0.80 | L3MBTL1 (0.50) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28222875 | 0.76 | HTT (0.40) | LMNAALDH1A1L3MBTL1MAPK1HTT | |
| SCHEMBL5929490 | 0.75 | MAPT (0.62) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10289213 | 0.74 | REN (0.50) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL78179 | 0.72 | KDM4E (0.43) | LMNAMAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL10289207 | 0.71 | OXTR (0.35) | L3MBTL1TDP1MEN1KMT2AHRH3 | |
| SCHEMBL14579984 | 0.69 | ALDH1A1 (0.56) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL17445912 | 0.69 | ALDH1A1 (0.66) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |